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Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
Science. 2013;342(6161):983-7 - PMID: 24158904 - PMCID: PMC4022187 - DOI: 10.1126/science.1245296

Zhao R, Fallon TR, Saladi SV, Pardo-Saganta A, Villoria J, Mou H, Vinarsky V, Gonzalez-Celeiro M, Nunna N, Hariri LP, Camargo F, Ellisen LW, Rajagopal J

Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells.
Dev Cell. 2014;30(2):151-65 - PMID: 25043474 - PMCID: PMC4130488 - DOI: 10.1016/j.devcel.2014.06.004

Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dančík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.
Proc Natl Acad Sci U S A. 2014;111(34):12468-73 - PMID: 25114223 - PMCID: PMC4151730 - DOI: 10.1073/pnas.1412308111

Kedrin D, Masia R, Nazarian RM, Garber JJ

Mycobacterium chelonae bacteremia after first dose of infliximab for ulcerative colitis.
Am J Gastroenterol. 2014;109(9):1501-2 - PMID: 25196883 - PMCID: PMC4423733 - DOI: 10.1038/ajg.2014.209

Hunt DP, Sahani DV, Corey KE, Masia R

Case records of the Massachusetts General Hospital. Case 30-2014. A 29-year-old man with diarrhea, nausea, and weight loss.
N Engl J Med. 2014;371(13):1238-47 - PMID: 25251619 - DOI: 10.1056/NEJMcpc1405218

Masia R, Peyton S, Lauwers GY, Brown I

Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases.
Am J Surg Pathol. 2014;38(10):1319-29 - PMID: 25188868 - PMCID: PMC4162848 - DOI: 10.1097/PAS.0000000000000317

Mordes DA, Lynch K, Campbell S, Dias-Santagata D, Nose V, Louis DN, Hoang MP

VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations.
Am J Clin Pathol. 2014;141(6):811-5 - PMID: 24838325 - DOI: 10.1309/AJCP37TLZLTUAOJL

Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL

Age-related clonal hematopoiesis associated with adverse outcomes.
N Engl J Med. 2014;371(26):2488-98 - PMID: 25426837 - PMCID: PMC4306669 - DOI: 10.1056/NEJMoa1408617

Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE

Genetic and epigenetic fine mapping of causal autoimmune disease variants.
Nature. 2014;518(7539):337-43 - PMID: 25363779 - PMCID: PMC4336207 - DOI: 10.1038/nature13835

Kleyman M, Kabeche L, Compton DA

STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.
J Cell Sci. 2014;127(Pt 19):4225-33 - PMID: 25074805 - PMCID: PMC4179491 - DOI: 10.1242/jcs.151613

Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA

DNA-damage response during mitosis induces whole-chromosome missegregation.
Cancer Discov. 2014;4(11):1281-9 - PMID: 25107667 - PMCID: PMC4221427 - DOI: 10.1158/2159-8290.CD-14-0403

Godek KM, Kabeche L, Compton DA

Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.
Nat Rev Mol Cell Biol. 2014;16(1):57-64 - PMID: 25466864 - PMCID: PMC4568440 - DOI: 10.1038/nrm3916

Oh J, Lee YD, Wagers AJ

Stem cell aging: mechanisms, regulators and therapeutic opportunities.
Nat Med. 2014;20(8):870-80 - PMID: 25100532 - PMCID: PMC4160113 - DOI: 10.1038/nm.3651

Masia R, Krause DS, Yellen G

The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.
Am J Physiol Cell Physiol. 2014;308(3):C264-76 - PMID: 25472961 - PMCID: PMC4312842 - DOI: 10.1152/ajpcell.00176.2014

Zheng X, Riant F, Bergametti F, Myers CD, Tang AT, Kleaveland B, Pan W, Yang J, Tournier-Lasserve E, Kahn ML

Cerebral cavernous malformations arise independent of the heart of glass receptor.
Stroke. 2014;45(5):1505-1509 - PMID: 24643410 - PMCID: PMC4006321 - DOI: 10.1161/STROKEAHA.114.004809

Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.
Nat Biotechnol. 2014;32(3):279-284 - PMID: 24463574 - PMCID: PMC3988262 - DOI: 10.1038/nbt.2808

Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.
Nat Methods. 2014;11(4):429-35 - PMID: 24531420 - PMCID: PMC4010127 - DOI: 10.1038/nmeth.2845

Sander JD, Joung JK

CRISPR-Cas systems for editing, regulating and targeting genomes.
Nat Biotechnol. 2014;32(4):347-55 - PMID: 24584096 - PMCID: PMC4022601 - DOI: 10.1038/nbt.2842

Gjini E, Mansour MR, Sander JD, Moritz N, Nguyen AT, Kesarsing M, Gans E, He S, Chen S, Ko M, Kuang YY, Yang S, Zhou Y, Rodig S, Zon LI, Joung JK, Rao A, Look AT

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.
Mol Cell Biol. 2014;35(5):789-804 - PMID: 25512612 - PMCID: PMC4323485 - DOI: 10.1128/MCB.00971-14

Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, Martinez SA, Chen EY, Lee C, Langenau DM

Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.
Cancer Cell. 2014;25(3):366-78 - PMID: 24613413 - PMCID: PMC3992437 - DOI: 10.1016/j.ccr.2014.01.032

Blackburn JS, Langenau DM

Zebrafish as a model to assess cancer heterogeneity, progression and relapse.
Dis Model Mech. 2014;7(7):755-62 - PMID: 24973745 - PMCID: PMC4073265 - DOI: 10.1242/dmm.015842

Tang Q, Abdelfattah NS, Blackburn JS, Moore JC, Martinez SA, Moore FE, Lobbardi R, Tenente IM, Ignatius MS, Berman JN, Liwski RS, Houvras Y, Langenau DM

Optimized cell transplantation using adult rag2 mutant zebrafish.
Nat Methods. 2014;11(8):821-4 - PMID: 25042784 - PMCID: PMC4294527 - DOI: 10.1038/nmeth.3031

Mihaylova MM, Sabatini DM, Yilmaz ÖH

Dietary and metabolic control of stem cell function in physiology and cancer.
Cell Stem Cell. 2014;14(3):292-305 - PMID: 24607404 - PMCID: PMC3992244 - DOI: 10.1016/j.stem.2014.02.008

Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.
Aging Cell. 2014;13(5):911-7 - PMID: 25059582 - PMCID: PMC4172536 - DOI: 10.1111/acel.12256

McMullin RP, Wittner BS, Yang C, Denton-Schneider BR, Hicks D, Singavarapu R, Moulis S, Lee J, Akbari MR, Narod SA, Aldape KD, Steeg PS, Ramaswamy S, Sgroi DC

A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.
Breast Cancer Res. 2014;16(2):R25 - PMID: 24625110 - PMCID: PMC4053087 - DOI: 10.1186/bcr3625

Wang M, Kern AM, Hülskötter M, Greninger P, Singh A, Pan Y, Chowdhury D, Krause M, Baumann M, Benes CH, Efstathiou JA, Settleman J, Willers H

EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation.
Cancer Res. 2014;74(10):2825-34 - PMID: 24648348 - PMCID: PMC4278592 - DOI: 10.1158/0008-5472.CAN-13-3157

Attanasio C, Nord AS, Zhu Y, Blow MJ, Biddie SC, Mendenhall EM, Dixon J, Wright C, Hosseini R, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Afzal V, Ren B, Bernstein BE, Rubin EM, Visel A, Pennacchio LA

Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis.
Genome Res. 2014;24(6):920-9 - PMID: 24752179 - PMCID: PMC4032856 - DOI: 10.1101/gr.168930.113

Pathak N, Austin-Tse CA, Liu Y, Vasilyev A, Drummond IA

Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
Mol Biol Cell. 2014;25(12):1836-44 - PMID: 24743595 - PMCID: PMC4055263 - DOI: 10.1091/mbc.E13-01-0033

Palmyre A, Lee J, Ryklin G, Camarata T, Selig MK, Duchemin AL, Nowak P, Arnaout MA, Drummond IA, Vasilyev A

Collective epithelial migration drives kidney repair after acute injury.
PLoS One. 2014;9(7):e101304 - PMID: 25010471 - PMCID: PMC4092191 - DOI: 10.1371/journal.pone.0101304

Fogelgren B, Zuo X, Buonato JM, Vasilyev A, Baek JI, Choi SY, Chacon-Heszele MF, Palmyre A, Polgar N, Drummond I, Park KM, Lazzara MJ, Lipschutz JH

Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis.
Am J Physiol Renal Physiol. 2014;307(12):F1334-41 - PMID: 25298525 - PMCID: PMC4269694 - DOI: 10.1152/ajprenal.00032.2014

Hariri LP, Applegate MB, Mino-Kenudson M, Mark EJ, Bouma BE, Tearney GJ, Suter MJ

Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation.
J Vis Exp. 2013;(71):ePub - PMID: 23381470 - PMCID: PMC3582683 - DOI: 10.3791/3855

Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK, Bernstein BE

Locus-specific editing of histone modifications at endogenous enhancers.
Nat Biotechnol. 2013;31(12):1133-6 - PMID: 24013198 - PMCID: PMC3858395 - DOI: 10.1038/nbt.2701

Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY

Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.
Cancer Discov. 2013;3(8):908-21 - PMID: 23719831 - PMCID: PMC3743121 - DOI: 10.1158/2159-8290.CD-12-0507

Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, Corcoran RB, Rivera MN, Ramaswamy S, Hung KE, Benes CH, Engelman JA

mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
Cancer Discov. 2013;4(1):42-52 - PMID: 24163374 - PMCID: PMC3973435 - DOI: 10.1158/2159-8290.CD-13-0315

Chen EY, Dobrinski KP, Brown KH, Clagg R, Edelman E, Ignatius MS, Chen JY, Brockmann J, Nielsen GP, Ramaswamy S, Keller C, Lee C, Langenau DM

Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.
PLoS Genet. 2013;9(8):e1003727 - PMID: 24009521 - PMCID: PMC3757044 - DOI: 10.1371/journal.pgen.1003727

Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.
Nat Biotechnol. 2013;31(12):1137-42 - PMID: 24108092 - PMCID: PMC3858462 - DOI: 10.1038/nbt.2726

Qi Y, Li X, Zhang Y, Starker CG, Baltes NJ, Zhang F, Sander JD, Reyon D, Joung JK, Voytas DF

Targeted deletion and inversion of tandemly arrayed genes in Arabidopsis thaliana using zinc finger nucleases.
G3 (Bethesda). 2013;3(10):1707-15 - PMID: 23979943 - PMCID: PMC3789795 - DOI: 10.1534/g3.113.006270

Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.
Nucleic Acids Res. 2013;41(19):e181 - PMID: 23945932 - PMCID: PMC3799455 - DOI: 10.1093/nar/gkt716

Hwang WY, Fu Y, Reyon D, Maeder ML, Kaini P, Sander JD, Joung JK, Peterson RT, Yeh JR

Heritable and precise zebrafish genome editing using a CRISPR-Cas system.
PLoS One. 2013;8(7):e68708 - PMID: 23874735 - PMCID: PMC3706373 - DOI: 10.1371/journal.pone.0068708

Reyon D, Maeder ML, Khayter C, Tsai SQ, Foley JE, Sander JD, Joung JK

Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly.
Curr Protoc Mol Biol. 2013;Chapter 12:Unit 12.16 - PMID: 23821439 - PMCID: PMC3767754 - DOI: 10.1002/0471142727.mb1216s103

Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.
Nat Biotechnol. 2013;31(9):822-6 - PMID: 23792628 - PMCID: PMC3773023 - DOI: 10.1038/nbt.2623

Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB, Bushman FD, Sinn PL, Craig NL

piggyBac transposase tools for genome engineering.
Proc Natl Acad Sci U S A. 2013;110(25):E2279-87 - PMID: 23723351 - PMCID: PMC3690869 - DOI: 10.1073/pnas.1305987110

Maeder ML, Linder SJ, Reyon D, Angstman JF, Fu Y, Sander JD, Joung JK

Robust, synergistic regulation of human gene expression using TALE activators.
Nat Methods. 2013;10(3):243-5 - PMID: 23396285 - PMCID: PMC3584229 - DOI: 10.1038/nmeth.2366

Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK

Efficient genome editing in zebrafish using a CRISPR-Cas system.
Nat Biotechnol. 2013;31(3):227-9 - PMID: 23360964 - PMCID: PMC3686313 - DOI: 10.1038/nbt.2501

Hariri LP, Mino-Kenudson M, Applegate MB, Mark EJ, Tearney GJ, Lanuti M, Channick CL, Chee A, Suter MJ

Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography.
Chest. 2013;144(4):1261-1268 - PMID: 23828441 - PMCID: PMC3787917 - DOI: 10.1378/chest.13-0534

Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.
Gastroenterology. 2013;145(6):1347-57 - PMID: 23973919 - PMCID: PMC3840157 - DOI: 10.1053/j.gastro.2013.08.035

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.
ACS Chem Biol. 2013;8(12):2724-2733 - PMID: 24168452 - PMCID: PMC3951132 - DOI: 10.1021/cb400352d

Conway KL, Kuballa P, Khor B, Zhang M, Shi HN, Virgin HW, Xavier RJ

ATG5 regulates plasma cell differentiation.
Autophagy. 2013;9(4):528-37 - PMID: 23327930 - PMCID: PMC3627668 - DOI: 10.4161/auto.23484

Hernandez-Lain A, Hedley-Whyte ET, Hariri LP, Molyneaux B, Nagle KJ, Cole AJ, Kilbride R

Pathology of bilateral pulvinar degeneration following long duration status epilepticus.
Seizure. 2013;22(10):901-4 - PMID: 23962521 - DOI: 10.1016/j.seizure.2013.07.012

Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts CWM, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub TR, Gordenin DA, Sunyaev S, Lander ES, Getz G

Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Nature. 2013;499(7457):214-218 - PMID: 23770567 - PMCID: PMC3919509 - DOI: 10.1038/nature12213
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