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Williams SR, Juratli TA, Castro BA, Lazaro TT, Gill CM, Nayyar N, Strickland MR, Babinski M, Johnstone SE, Frosch MP, Silverman IM, Ely HA, Kaplan AB, D'Andrea MR, Bihun IV, Hoang K, Batchelor E, Christiansen J, Cahill DP, Barker FG, Brastianos PK

Genomic Analysis of Posterior Fossa Meningioma Demonstrates Frequent AKT1 E17K Mutations in Foramen Magnum Meningiomas.
J Neurol Surg B Skull Base. 2019;80(6):562-567 - PMID: 31750041 - PMCID: PMC6864425 - DOI: 10.1055/s-0038-1676821

Hanlon KS, Kleinstiver BP, Garcia SP, Zaborowski MP, Volak A, Spirig SE, Muller A, Sousa AA, Tsai SQ, Bengtsson NE, Lööv C, Ingelsson M, Chamberlain JS, Corey DP, Aryee MJ, Joung JK, Breakefield XO, Maguire CA, György B

High levels of AAV vector integration into CRISPR-induced DNA breaks.
Nat Commun. 2019;10(1):4439 - PMID: 31570731 - PMCID: PMC6769011 - DOI: 10.1038/s41467-019-12449-2

Guiney TE, Lopes MS, Kalra MK, Mooradian MJ, Neilan TG, Stone JR

Case 30-2019: A 65-Year-Old Woman with Lung Cancer and Chest Pain.
N Engl J Med. 2019;381(13):1268-1277 - PMID: 31553841 - DOI: 10.1056/NEJMcpc1900423

Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ

Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements.
Cell. 2019;179(1):251-267.e24 - PMID: 31539496 - PMCID: PMC6934691 - DOI: 10.1016/j.cell.2019.08.013

Prabhakar S, Cheah PS, Zhang X, Zinter M, Gianatasio M, Hudry E, Bronson RT, Kwiatkowski DJ, Stemmer-Rachamimov A, Maguire CA, Sena-Esteves M, Tannous BA, Breakefield XO

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.
Mol Ther Methods Clin Dev. 2019;15:18-26 - PMID: 31534984 - PMCID: PMC6745533 - DOI: 10.1016/j.omtm.2019.08.003

Champion SN, Stone JR

Immune checkpoint inhibitor associated myocarditis occurs in both high-grade and low-grade forms.
Mod Pathol. 2019;33(1):99-108 - PMID: 31534205 - DOI: 10.1038/s41379-019-0363-0

Newman JL, Stone JR

Immune checkpoint inhibition alters the inflammatory cell composition of human coronary artery atherosclerosis.
Cardiovasc Pathol. 2019;43:107148 - PMID: 31518915 - DOI: 10.1016/j.carpath.2019.107148

Black M, Liu CZ, Onozato M, Iafrate AJ, Darvishian F, Jour G, Cotzia P

Concurrent Identification of Novel EGFR-SEPT14 Fusion and ETV6-RET Fusion in Secretory Carcinoma of the Salivary Gland.
Head Neck Pathol. 2019;14(3):817-821 - PMID: 31502214 - PMCID: PMC7413937 - DOI: 10.1007/s12105-019-01074-6

Grünewald J, Zhou R, Iyer S, Lareau CA, Garcia SP, Aryee MJ, Joung JK

CRISPR DNA base editors with reduced RNA off-target and self-editing activities.
Nat Biotechnol. 2019;37(9):1041-1048 - PMID: 31477922 - PMCID: PMC6730565 - DOI: 10.1038/s41587-019-0236-6

Tilgner M, Vater TS, Habbel P, Cheng LL

High-Resolution Magic Angle Spinning (HRMAS) NMR Methods in Metabolomics.
Methods Mol Biol. 2019;2037:49-67 - PMID: 31463839 - DOI: 10.1007/978-1-4939-9690-2_4

Joseph NM, Tsokos CG, Umetsu SE, Shain AH, Kelley RK, Onodera C, Bowman S, Talevich E, Ferrell LD, Kakar S, Krings G

Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma.
J Pathol. 2019;248(2):164-178 - PMID: 30690729 - DOI: 10.1002/path.5243

Solomon IH, Lin C, Horback KL, Kanjilal S, Rojas-Rudilla V, Brigl M, Laga AC, Lindeman NI, Padera RF

Utility of Histologic and Histochemical Screening for 16S Ribosomal RNA Gene Sequencing of Formalin-Fixed, Paraffin-Embedded Tissue for Bacterial Endocarditis.
Am J Clin Pathol. 2019;152(4):431-437 - PMID: 31172185 - DOI: 10.1093/ajcp/aqz055

Nagaraja S, Quezada MA, Gillespie SM, Arzt M, Lennon JJ, Woo PJ, Hovestadt V, Kambhampati M, Filbin MG, Suva ML, Nazarian J, Monje M

Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State.
Mol Cell. 2019;76(6):965-980.e12 - PMID: 31588023 - PMCID: PMC7104854 - DOI: 10.1016/j.molcel.2019.08.030

Flavahan WA, Drier Y, Johnstone SE, Hemming ML, Tarjan DR, Hegazi E, Shareef SJ, Javed NM, Raut CP, Eschle BK, Gokhale PC, Hornick JL, Sicinska ET, Demetri GD, Bernstein BE

Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs.
Nature. 2019;575(7781):229-233 - PMID: 31666694 - PMCID: PMC6913936 - DOI: 10.1038/s41586-019-1668-3

Wu S, Lin SX, Lu M, Subtelny AO, Wang Z, Dahl DM, Olumi AF, Wu CL

Assessment of 5-year overall survival in bladder cancer patients with incidental prostate cancer identified at radical cystoprostatectomy.
Int Urol Nephrol. 2019;51(9):1527-1535 - PMID: 31183659 - DOI: 10.1007/s11255-019-02181-7

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM

Tissue-Specific Oncogenic Activity of KRASA146T.
Cancer Discov. 2019;9(6):738-755 - PMID: 30952657 - PMCID: PMC6548671 - DOI: 10.1158/2159-8290.CD-18-1220

Sontheimer-Phelps A, Chou DB, Tovaglieri A, Ferrante TC, Duckworth T, Fadel C, Frismantas V, Sutherland AD, Jalili-Firoozinezhad S, Kasendra M, Stas E, Weaver JC, Richmond CA, Levy O, Prantil-Baun R, Breault DT, Ingber DE

Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology.
Cell Mol Gastroenterol Hepatol. 2019;9(3):507-526 - PMID: 31778828 - PMCID: PMC7036549 - DOI: 10.1016/j.jcmgh.2019.11.008

Leijssen LGJ, Dinaux AM, Amri R, Taylor MS, Deshpande V, Bordeianou LG, Kunitake H, Berger DL

Impact of intramural and extramural vascular invasion on stage II-III colon cancer outcomes.
J Surg Oncol. 2019;119(6):749-757 - PMID: 30644557 - PMCID: PMC6629581 - DOI: 10.1002/jso.25367

Cai L, Michelakos T, Deshpande V, Arora KS, Yamada T, Ting DT, Taylor MS, Castillo CF, Warshaw AL, Lillemoe KD, Ferrone S, Ferrone CR

Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs).
Clin Cancer Res. 2019;25(8):2644-2655 - PMID: 30670493 - PMCID: PMC6582654 - DOI: 10.1158/1078-0432.CCR-18-1401

Taylor MS, Chougule A, MacLeay AR, Kurzawa P, Chebib I, Le L, Deshpande V

Morphologic Overlap Between Inflammatory Myofibroblastic Tumor and IgG4-related Disease: Lessons From Next-generation Sequencing.
Am J Surg Pathol. 2019;43(3):314-324 - PMID: 30451733 - PMCID: PMC6637760 - DOI: 10.1097/PAS.0000000000001167

Chougule A, Taylor MS, Nardi V, Chebib I, Cote GM, Choy E, Nielsen GP, Deshpande V

Spindle and Round Cell Sarcoma With EWSR1-PATZ1 Gene Fusion: A Sarcoma With Polyphenotypic Differentiation.
Am J Surg Pathol. 2019;43(2):220-228 - PMID: 30379650 - PMCID: PMC6590674 - DOI: 10.1097/PAS.0000000000001183

Choi BD, Yu X, Castano AP, Darr H, Henderson DB, Bouffard AA, Larson RC, Scarfò I, Bailey SR, Gerhard GM, Frigault MJ, Leick MB, Schmidts A, Sagert JG, Curry WT, Carter BS, Maus MV

CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma.
J Immunother Cancer. 2019;7(1):304 - PMID: 31727131 - PMCID: PMC6857271 - DOI: 10.1186/s40425-019-0806-7

Cheng CW, Biton M, Haber AL, Gunduz N, Eng G, Gaynor LT, Tripathi S, Calibasi-Kocal G, Rickelt S, Butty VL, Moreno-Serrano M, Iqbal AM, Bauer-Rowe KE, Imada S, Ulutas MS, Mylonas C, Whary MT, Levine SS, Basbinar Y, Hynes RO, Mino-Kenudson M, Deshpande V, Boyer LA, Fox JG, Terranova C, Rai K, Piwnica-Worms H, Mihaylova MM, Regev A, Yilmaz ÖH

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.
Cell. 2019;178(5):1115-1131.e15 - PMID: 31442404 - PMCID: PMC6732196 - DOI: 10.1016/j.cell.2019.07.048

Walley AY, Wakeman SE, Eng G

Case 6-2019: A 29-Year-Old Woman with Nausea, Vomiting, and Diarrhea.
N Engl J Med. 2019;380(8):772-779 - PMID: 30786192 - DOI: 10.1056/NEJMcpc1816407

Bailey SR, Maus MV

Gene editing for immune cell therapies.
Nat Biotechnol. 2019;37(12):1425-1434 - PMID: 31160723 - DOI: 10.1038/s41587-019-0137-8

Hu X, Xiang D, Xie Y, Tao L, Zhang Y, Jin Y, Pinello L, Wan Y, Yuan GC, Li Z

LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression.
Oncogene. 2019;38(44):7017-7034 - PMID: 31409898 - PMCID: PMC6823153 - DOI: 10.1038/s41388-019-0923-2

Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, Auvinen P, Ristimäki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz ÖH, Katajisto P

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
Nature. 2019;571(7765):398-402 - PMID: 31292548 - PMCID: PMC8151802 - DOI: 10.1038/s41586-019-1383-0

Hariri LP, Adams DC, Applegate MB, Miller AJ, Roop BW, Villiger M, Bouma BE, Suter MJ

Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography.
Clin Cancer Res. 2019;25(17):5242-5249 - PMID: 31175092 - PMCID: PMC6726561 - DOI: 10.1158/1078-0432.CCR-19-0566

Adams DC, Miller AJ, Applegate MB, Cho JL, Hamilos DL, Chee A, Holz JA, Szabari MV, Hariri LP, Harris RS, Griffith JW, Luster AD, Medoff BD, Suter MJ

Quantitative assessment of airway remodelling and response to allergen in asthma.
Respirology. 2019;24(11):1073-1080 - PMID: 30845351 - PMCID: PMC6732047 - DOI: 10.1111/resp.13521

Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Nat Neurosci. 2019;22(2):167-179 - PMID: 30643292 - PMCID: PMC7153761 - DOI: 10.1038/s41593-018-0300-4

Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM

Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.
PLoS Pathog. 2019;15(6):e1007846 - PMID: 31163081 - PMCID: PMC6548391 - DOI: 10.1371/journal.ppat.1007846

Hicks ND, Carey AF, Yang J, Zhao Y, Fortune SM

Bacterial Genome-Wide Association Identifies Novel Factors That Contribute to Ethionamide and Prothionamide Susceptibility in Mycobacterium tuberculosis.
MBio. 2019;10(2):ePub - PMID: 31015328 - PMCID: PMC6479004 - DOI: 10.1128/mBio.00616-19

Tovaglieri A, Sontheimer-Phelps A, Geirnaert A, Prantil-Baun R, Camacho DM, Chou DB, Jalili-Firoozinezhad S, de Wouters T, Kasendra M, Super M, Cartwright MJ, Richmond CA, Breault DT, Lacroix C, Ingber DE

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites.
Microbiome. 2019;7(1):43 - PMID: 30890187 - PMCID: PMC6425591 - DOI: 10.1186/s40168-019-0650-5

Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ

T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes.
Cell. 2019;178(4):1016-1028.e13 - PMID: 31398327 - PMCID: PMC6939866 - DOI: 10.1016/j.cell.2019.07.009

Ormhøj M, Scarfò I, Cabral ML, Bailey SR, Lorrey SJ, Bouffard AA, Castano AP, Larson RC, Riley LS, Schmidts A, Choi BD, Andersen RS, Cédile O, Nyvold CG, Christensen JH, Gjerstorff MF, Ditzel HJ, Weinstock DM, Barington T, Frigault MJ, Maus MV

Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19.
Clin Cancer Res. 2019;25(23):7046-7057 - PMID: 31439577 - PMCID: PMC6891163 - DOI: 10.1158/1078-0432.CCR-19-1337

Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, Wakimoto H, Curry WT, Carter BS, Maus MV

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity.
Nat Biotechnol. 2019;37(9):1049-1058 - PMID: 31332324 - DOI: 10.1038/s41587-019-0192-1

Berker Y, Vandergrift LA, Wagner I, Su L, Kurth J, Schuler A, Dinges SS, Habbel P, Nowak J, Mark E, Aryee MJ, Christiani DC, Cheng LL

Magnetic Resonance Spectroscopy-based Metabolomic Biomarkers for Typing, Staging, and Survival Estimation of Early-Stage Human Lung Cancer.
Sci Rep. 2019;9(1):10319 - PMID: 31311965 - PMCID: PMC6635503 - DOI: 10.1038/s41598-019-46643-5

Ortonne N, Carroll SL, Rodriguez FJ, Miller DC, Nazarian RM, Blakeley JO, Madaj ZB, Verma SK, Stemmer-Rachamimov A

Assessing interobserver variability and accuracy in the histological diagnosis and classification of cutaneous neurofibromass.
Neurooncol Adv. 2019;2(Suppl 1):i117-i123 - PMID: 32642737 - PMCID: PMC7317056 - DOI: 10.1093/noajnl/vdz050

Erturk-Hasdemir D, Oh SF, Okan NA, Stefanetti G, Gazzaniga FS, Seeberger PH, Plevy SE, Kasper DL

Symbionts exploit complex signaling to educate the immune system.
Proc Natl Acad Sci U S A. 2019;116(52):26157-26166 - PMID: 31811024 - PMCID: PMC6936714 - DOI: 10.1073/pnas.1915978116

Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Kubota K, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Sekiguchi H, Schleinitz N, Stone JR, Takahashi N, Umehara H, Webster G, Zen Y, Stone JH, American College of Rheumatology/European League Against Rheumatism IgG4-Related Disease Classification Criteria Working Group

The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease.
Arthritis Rheumatol. 2019;72(1):7-19 - PMID: 31793250 - DOI: 10.1002/art.41120

Chen H, Lareau C, Andreani T, Vinyard ME, Garcia SP, Clement K, Andrade-Navarro MA, Buenrostro JD, Pinello L

Assessment of computational methods for the analysis of single-cell ATAC-seq data.
Genome Biol. 2019;20(1):241 - PMID: 31739806 - PMCID: PMC6859644 - DOI: 10.1186/s13059-019-1854-5

Hsu A, Bhattacharya KR, Chan HK, Huber TC, Gardner B, Stone JR, Angle JF

Effect of timing on endovascular therapy and exploratory laparotomy outcome in acute mesenteric ischemia.
Ann Gastroenterol. 2019;32(6):600-604 - PMID: 31700237 - PMCID: PMC6826075 - DOI: 10.20524/aog.2019.0419

Ma M, Ramirez AD, Wang T, Roberts RL, Harmon KE, Schoppik D, Sharma A, Kuang C, Goei SL, Gagnon JA, Zimmerman S, Tsai SQ, Reyon D, Joung JK, Aksay ERF, Schier AF, Pan YA

Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function.
J Neurosci. 2019;40(1):143-158 - PMID: 31685652 - PMCID: PMC6939486 - DOI: 10.1523/JNEUROSCI.1783-19.2019

Menon M, Mohammadi S, Davila-Velderrain J, Goods BA, Cadwell TD, Xing Y, Stemmer-Rachamimov A, Shalek AK, Love JC, Kellis M, Hafler BP

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration.
Nat Commun. 2019;10(1):4902 - PMID: 31653841 - PMCID: PMC6814749 - DOI: 10.1038/s41467-019-12780-8

Hillier K, Hughes A, Shamberger RC, Shusterman S, Perez-Atayde AR, Wassner AJ, Iafrate AJ, Dubuc A, Janeway KA, Rothenberg SM, Cox MC, Randolph GW, Wirth LJ, Tsai H, Church A, DuBois SG

A Novel ALK Fusion in Pediatric Medullary Thyroid Carcinoma.
Thyroid. 2019;29(11):1704-1707 - PMID: 31650892 - DOI: 10.1089/thy.2019.0041

Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.
Cancer Cell. 2019;36(5):528-544.e10 - PMID: 31631026 - DOI: 10.1016/j.ccell.2019.09.005

Bigler ED, Abildskov TJ, Eggleston B, Taylor BA, Tate DF, Petrie JA, Newsome MR, Scheibel RS, Levin H, Walker WC, Goodrich-Hunsaker N, Tustison NJ, Stone JR, Mayer AR, Duncan TD, York GE, Wilde EA

Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study.
Int J Methods Psychiatr Res. 2019;28(3):e1781 - PMID: 31608535 - PMCID: PMC6877164 - DOI: 10.1002/mpr.1781

Costa C, Wang Y, Ly A, Hosono Y, Murchie E, Walmsley CS, Huynh T, Healy C, Peterson R, Yanase S, Jakubik CT, Henderson LE, Damon LJ, Timonina D, Sanidas I, Pinto CJ, Mino-Kenudson M, Stone JR, Dyson NJ, Ellisen LW, Bardia A, Ebi H, Benes CH, Engelman JA, Juric D

PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer.
Cancer Discov. 2019;10(1):72-85 - PMID: 31594766 - DOI: 10.1158/2159-8290.CD-18-0830
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