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Blackburn JS, Langenau DM

Zebrafish as a model to assess cancer heterogeneity, progression and relapse.
Dis Model Mech. 2014;7(7):755-62 - PMID: 24973745 - PMCID: PMC4073265 - DOI: 10.1242/dmm.015842

Hariri LP, Mino-Kenudson M, Lanuti M, Miller AJ, Mark EJ, Suter MJ

Diagnosing lung carcinomas with optical coherence tomography.
Ann Am Thorac Soc. 2015;12(2):193-201 - PMID: 25562183 - PMCID: PMC4342833 - DOI: 10.1513/AnnalsATS.201408-370OC

Rogers JM, Barrera LA, Reyon D, Sander JD, Kellis M, Joung JK, Bulyk ML

Context influences on TALE-DNA binding revealed by quantitative profiling.
Nat Commun. 2015;6:7440 - PMID: 26067805 - PMCID: PMC4467457 - DOI: 10.1038/ncomms8440

Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity.
Nat Methods. 2015;12(10):939-42 - PMID: 26258293 - PMCID: PMC4589463 - DOI: 10.1038/nmeth.3515

Faber AC, Farago AF, Costa C, Dastur A, Gomez-Caraballo M, Robbins R, Wagner BL, Rideout WM, Jakubik CT, Ham J, Edelman EJ, Ebi H, Yeo AT, Hata AN, Song Y, Patel NU, March RJ, Tam AT, Milano RJ, Boisvert JL, Hicks MA, Elmiligy S, Malstrom SE, Rivera MN, Harada H, Windle BE, Ramaswamy S, Benes CH, Jacks T, Engelman JA

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.
Proc Natl Acad Sci U S A. 2015;112(11):E1288-96 - PMID: 25737542 - PMCID: PMC4371986 - DOI: 10.1073/pnas.1411848112

van Galen P, Viny AD, Ram O, Ryan RJ, Cotton MJ, Donohue L, Sievers C, Drier Y, Liau BB, Gillespie SM, Carroll KM, Cross MB, Levine RL, Bernstein BE

A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes.
Mol Cell. 2015;61(1):170-80 - PMID: 26687680 - PMCID: PMC4707994 - DOI: 10.1016/j.molcel.2015.11.003

Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.
Science. 2015;347(6219):273-7 - PMID: 25593184 - PMCID: PMC4358324 - DOI: 10.1126/science.1257216

Krause DS, Scadden DT

A hostel for the hostile: the bone marrow niche in hematologic neoplasms.
Haematologica. 2015;100(11):1376-87 - PMID: 26521296 - PMCID: PMC4825315 - DOI: 10.3324/haematol.2014.113852

Berger AH, Imielinski M, Duke F, Wala J, Kaplan N, Shi GX, Andres DA, Meyerson M

Oncogenic RIT1 mutations in lung adenocarcinoma.
Oncogene. 2014;33(35):4418-23 - PMID: 24469055 - PMCID: PMC4150988 - DOI: 10.1038/onc.2013.581

Brooks AN, Choi PS, de Waal L, Sharifnia T, Imielinski M, Saksena G, Pedamallu CS, Sivachenko A, Rosenberg M, Chmielecki J, Lawrence MS, DeLuca DS, Getz G, Meyerson M

A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events.
PLoS One. 2014;9(1):e87361 - PMID: 24498085 - PMCID: PMC3909098 - DOI: 10.1371/journal.pone.0087361

Imielinski M, Greulich H, Kaplan B, Araujo L, Amann J, Horn L, Schiller J, Villalona-Calero MA, Meyerson M, Carbone DP

Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.
J Clin Invest. 2014;124(4):1582-6 - PMID: 24569458 - PMCID: PMC3973082 - DOI: 10.1172/JCI72763

Cancer Genome Atlas Research Network

Comprehensive molecular profiling of lung adenocarcinoma.
Nature. 2014;511(7511):543-50 - PMID: 25079552 - PMCID: PMC4231481 - DOI: 10.1038/nature13385

Sharifnia T, Rusu V, Piccioni F, Bagul M, Imielinski M, Cherniack AD, Pedamallu CS, Wong B, Wilson FH, Garraway LA, Altshuler D, Golub TR, Root DE, Subramanian A, Meyerson M

Genetic modifiers of EGFR dependence in non-small cell lung cancer.
Proc Natl Acad Sci U S A. 2014;111(52):18661-6 - PMID: 25512530 - PMCID: PMC4284598 - DOI: 10.1073/pnas.1412228112

Zhao R, Fallon TR, Saladi SV, Pardo-Saganta A, Villoria J, Mou H, Vinarsky V, Gonzalez-Celeiro M, Nunna N, Hariri LP, Camargo F, Ellisen LW, Rajagopal J

Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells.
Dev Cell. 2014;30(2):151-65 - PMID: 25043474 - PMCID: PMC4130488 - DOI: 10.1016/j.devcel.2014.06.004

Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dančík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.
Proc Natl Acad Sci U S A. 2014;111(34):12468-73 - PMID: 25114223 - PMCID: PMC4151730 - DOI: 10.1073/pnas.1412308111

Kedrin D, Masia R, Nazarian RM, Garber JJ

Mycobacterium chelonae bacteremia after first dose of infliximab for ulcerative colitis.
Am J Gastroenterol. 2014;109(9):1501-2 - PMID: 25196883 - PMCID: PMC4423733 - DOI: 10.1038/ajg.2014.209

Hunt DP, Sahani DV, Corey KE, Masia R

Case records of the Massachusetts General Hospital. Case 30-2014. A 29-year-old man with diarrhea, nausea, and weight loss.
N Engl J Med. 2014;371(13):1238-47 - PMID: 25251619 - DOI: 10.1056/NEJMcpc1405218

Masia R, Peyton S, Lauwers GY, Brown I

Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases.
Am J Surg Pathol. 2014;38(10):1319-29 - PMID: 25188868 - PMCID: PMC4162848 - DOI: 10.1097/PAS.0000000000000317

Mordes DA, Lynch K, Campbell S, Dias-Santagata D, Nose V, Louis DN, Hoang MP

VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations.
Am J Clin Pathol. 2014;141(6):811-5 - PMID: 24838325 - DOI: 10.1309/AJCP37TLZLTUAOJL

Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL

Age-related clonal hematopoiesis associated with adverse outcomes.
N Engl J Med. 2014;371(26):2488-98 - PMID: 25426837 - PMCID: PMC4306669 - DOI: 10.1056/NEJMoa1408617

Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE

Genetic and epigenetic fine mapping of causal autoimmune disease variants.
Nature. 2014;518(7539):337-43 - PMID: 25363779 - PMCID: PMC4336207 - DOI: 10.1038/nature13835

Kleyman M, Kabeche L, Compton DA

STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.
J Cell Sci. 2014;127(Pt 19):4225-33 - PMID: 25074805 - PMCID: PMC4179491 - DOI: 10.1242/jcs.151613

Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA

DNA-damage response during mitosis induces whole-chromosome missegregation.
Cancer Discov. 2014;4(11):1281-9 - PMID: 25107667 - PMCID: PMC4221427 - DOI: 10.1158/2159-8290.CD-14-0403

Godek KM, Kabeche L, Compton DA

Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.
Nat Rev Mol Cell Biol. 2014;16(1):57-64 - PMID: 25466864 - PMCID: PMC4568440 - DOI: 10.1038/nrm3916

Oh J, Lee YD, Wagers AJ

Stem cell aging: mechanisms, regulators and therapeutic opportunities.
Nat Med. 2014;20(8):870-80 - PMID: 25100532 - PMCID: PMC4160113 - DOI: 10.1038/nm.3651

Masia R, Krause DS, Yellen G

The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.
Am J Physiol Cell Physiol. 2014;308(3):C264-76 - PMID: 25472961 - PMCID: PMC4312842 - DOI: 10.1152/ajpcell.00176.2014

Zheng X, Riant F, Bergametti F, Myers CD, Tang AT, Kleaveland B, Pan W, Yang J, Tournier-Lasserve E, Kahn ML

Cerebral cavernous malformations arise independent of the heart of glass receptor.
Stroke. 2014;45(5):1505-1509 - PMID: 24643410 - PMCID: PMC4006321 - DOI: 10.1161/STROKEAHA.114.004809

Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.
Nat Biotechnol. 2014;32(3):279-284 - PMID: 24463574 - PMCID: PMC3988262 - DOI: 10.1038/nbt.2808

Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.
Nat Methods. 2014;11(4):429-35 - PMID: 24531420 - PMCID: PMC4010127 - DOI: 10.1038/nmeth.2845

Sander JD, Joung JK

CRISPR-Cas systems for editing, regulating and targeting genomes.
Nat Biotechnol. 2014;32(4):347-55 - PMID: 24584096 - PMCID: PMC4022601 - DOI: 10.1038/nbt.2842

Gjini E, Mansour MR, Sander JD, Moritz N, Nguyen AT, Kesarsing M, Gans E, He S, Chen S, Ko M, Kuang YY, Yang S, Zhou Y, Rodig S, Zon LI, Joung JK, Rao A, Look AT

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.
Mol Cell Biol. 2014;35(5):789-804 - PMID: 25512612 - PMCID: PMC4323485 - DOI: 10.1128/MCB.00971-14

Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, Martinez SA, Chen EY, Lee C, Langenau DM

Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.
Cancer Cell. 2014;25(3):366-78 - PMID: 24613413 - PMCID: PMC3992437 - DOI: 10.1016/j.ccr.2014.01.032

Conway KL, Kuballa P, Khor B, Zhang M, Shi HN, Virgin HW, Xavier RJ

ATG5 regulates plasma cell differentiation.
Autophagy. 2013;9(4):528-37 - PMID: 23327930 - PMCID: PMC3627668 - DOI: 10.4161/auto.23484

Reyon D, Maeder ML, Khayter C, Tsai SQ, Foley JE, Sander JD, Joung JK

Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly.
Curr Protoc Mol Biol. 2013;Chapter 12:Unit 12.16 - PMID: 23821439 - PMCID: PMC3767754 - DOI: 10.1002/0471142727.mb1216s103

Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.
Nat Biotechnol. 2013;31(9):822-6 - PMID: 23792628 - PMCID: PMC3773023 - DOI: 10.1038/nbt.2623

Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB, Bushman FD, Sinn PL, Craig NL

piggyBac transposase tools for genome engineering.
Proc Natl Acad Sci U S A. 2013;110(25):E2279-87 - PMID: 23723351 - PMCID: PMC3690869 - DOI: 10.1073/pnas.1305987110

Maeder ML, Linder SJ, Reyon D, Angstman JF, Fu Y, Sander JD, Joung JK

Robust, synergistic regulation of human gene expression using TALE activators.
Nat Methods. 2013;10(3):243-5 - PMID: 23396285 - PMCID: PMC3584229 - DOI: 10.1038/nmeth.2366

Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK

Efficient genome editing in zebrafish using a CRISPR-Cas system.
Nat Biotechnol. 2013;31(3):227-9 - PMID: 23360964 - PMCID: PMC3686313 - DOI: 10.1038/nbt.2501

Hariri LP, Mino-Kenudson M, Applegate MB, Mark EJ, Tearney GJ, Lanuti M, Channick CL, Chee A, Suter MJ

Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography.
Chest. 2013;144(4):1261-1268 - PMID: 23828441 - PMCID: PMC3787917 - DOI: 10.1378/chest.13-0534

Hariri LP, Applegate MB, Mino-Kenudson M, Mark EJ, Bouma BE, Tearney GJ, Suter MJ

Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation.
J Vis Exp. 2013;(71):ePub - PMID: 23381470 - PMCID: PMC3582683 - DOI: 10.3791/3855

Hariri LP, Villiger M, Applegate MB, Mino-Kenudson M, Mark EJ, Bouma BE, Suter MJ

Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy.
Am J Respir Crit Care Med. 2013;187(2):125-9 - PMID: 23322794 - PMCID: PMC3570655 - DOI: 10.1164/rccm.201208-1483OE

Hariri LP, Applegate MB, Mino-Kenudson M, Mark EJ, Medoff BD, Luster AD, Bouma BE, Tearney GJ, Suter MJ

Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology.
Chest. 2013;143(1):64-74 - PMID: 22459781 - PMCID: PMC3537541 - DOI: 10.1378/chest.11-2797

Kabeche L, Compton DA

Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
Nature. 2013;502(7469):110-3 - PMID: 24013174 - PMCID: PMC3791168 - DOI: 10.1038/nature12507

Wang CI, Alekseyenko AA, LeRoy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI

Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila.
Nat Struct Mol Biol. 2013;20(2):202-9 - PMID: 23295261 - PMCID: PMC3674866 - DOI: 10.1038/nsmb.2477

Ryan DP, Friedmann AM, Schmitz MD, Ryan RJ

Case records of the Massachusetts General Hospital. Case 11-2013. A 4-year-old boy with fever and abdominal pain.
N Engl J Med. 2013;368(15):1435-44 - PMID: 23574123 - DOI: 10.1056/NEJMcpc1209304

Gupta NK, Masia R

Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract.
Am J Surg Pathol. 2013;37(7):1109-13 - PMID: 23715165 - PMCID: PMC3687023 - DOI: 10.1097/PAS.0b013e31828a827a

Bender SL, Sherry NA, Masia R

Case records of the Massachusetts General Hospital. Case 16-2013. A 12-year-old girl with irritability, hypersomnia, and somatic symptoms.
N Engl J Med. 2013;368(21):2015-24 - PMID: 23697517 - PMCID: PMC4766583 - DOI: 10.1056/NEJMcpc1208145

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.
ACS Chem Biol. 2013;8(12):2724-2733 - PMID: 24168452 - PMCID: PMC3951132 - DOI: 10.1021/cb400352d

Attanasio C, Nord AS, Zhu Y, Blow MJ, Biddie SC, Mendenhall EM, Dixon J, Wright C, Hosseini R, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Afzal V, Ren B, Bernstein BE, Rubin EM, Visel A, Pennacchio LA

Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis.
Genome Res. 2014;24(6):920-9 - PMID: 24752179 - PMCID: PMC4032856 - DOI: 10.1101/gr.168930.113

Wang M, Kern AM, Hülskötter M, Greninger P, Singh A, Pan Y, Chowdhury D, Krause M, Baumann M, Benes CH, Efstathiou JA, Settleman J, Willers H

EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation.
Cancer Res. 2014;74(10):2825-34 - PMID: 24648348 - PMCID: PMC4278592 - DOI: 10.1158/0008-5472.CAN-13-3157
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