CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing.
T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation.
Cancer Cell. 2024;42(6):1130-1131 - PMID: 38861925 - PMCID: PMC11253892 - DOI: 10.1016/j.ccell.2024.05.019
Large B-cell lymphoma with mystery rearrangement: Applying Hi-C to the detection of clinically relevant structural abnormalities.
Br J Haematol. 2024;205(3):1225-1229 - PMID: 38924537 - DOI: 10.1111/bjh.19611
Single-cell atlas of the human brain vasculature across development, adulthood and disease.
Nature. 2024;632(8025):603-613 - PMID: 38987604 - PMCID: PMC11324530 - DOI: 10.1038/s41586-024-07493-y
Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma.
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma.
JCI Insight. 2024;9(14):ePub - PMID: 39133652 - PMCID: PMC11383371 - DOI: 10.1172/jci.insight.169647
EPInformer: A Scalable Deep Learning Framework for Gene Expression Prediction by Integrating Promoter-enhancer Sequences with Multimodal Epigenomic Data.
Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors.
Adv Sci (Weinh). 2024;11(38):e2309755 - PMID: 39136172 - PMCID: PMC11481286 - DOI: 10.1002/advs.202309755
Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors.
Cancer Cell. 2024;42(9):1497-1506 - PMID: 39214095 - DOI: 10.1016/j.ccell.2024.08.005
Scalable assessment of genome editing off-targets associated with genetic variants.
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
Case 27-2024: A 24-Year-Old Man with Pain and Dyspnea.
N Engl J Med. 2024;391(9):845-852 - PMID: 39231348 - DOI: 10.1056/NEJMcpc2402491
Normative Neuroimaging Library: Designing a Comprehensive and Demographically Diverse Dataset of Healthy Controls to Support Traumatic Brain Injury Diagnostic and Therapeutic Development.
J Neurotrauma. 2024;41(23-24):2497-2512 - PMID: 39235436 - DOI: 10.1089/neu.2024.0128
Selective Enhancer Gain of Function Deregulates MYC Expression in Multiple Myeloma.
Cancer Res. 2024;84(24):4173-4183 - PMID: 39312195 - PMCID: PMC11649448 - DOI: 10.1158/0008-5472.CAN-24-1440
Erratum: Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2.
Mol Ther Methods Clin Dev. 2024;32(2):101262 - PMID: 38745896 - PMCID: PMC11090857 - DOI: 10.1016/j.omtm.2024.101262
Glioblastoma-cortical organoids recapitulate cell state heterogeneity and intercellular transfer.
Cancer Discov. 2024;15(2):299-315 - PMID: 39373549 - PMCID: PMC11803396 - DOI: 10.1158/2159-8290.CD-23-1336
Association between thrombus histopathology and hemodynamic outcomes among patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy.
Chest. 2024;167(4):1182-1190 - PMID: 39454997 - DOI: 10.1016/j.chest.2024.10.018
Follicular lymphoma research: an open dialogue for a collaborative roadmap.
Building social equity and person-centred innovation into the end TB response.
Int J Tuberc Lung Dis. 2024;28(11):517-520 - PMID: 39468025 - DOI: 10.5588/ijtld.24.0338
Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations.
Nat Methods. 2024;21(12):2271-2286 - PMID: 39482463 - PMCID: PMC11621032 - DOI: 10.1038/s41592-024-02471-8
Consensus recommendations for an integrated diagnostic approach to peripheral nerve sheath tumors arising in the setting of Neurofibromatosis type 1 (NF1).
Immune responses in checkpoint myocarditis across heart, blood and tumour.
Nature. 2024;636(8041):215-223 - PMID: 39506125 - DOI: 10.1038/s41586-024-08105-5
Differences in Brain Volume in Military Service Members and Veterans After Blast-Related Mild TBI: A LIMBIC-CENC Study.
JAMA Netw Open. 2024;7(11):e2443416 - PMID: 39527059 - PMCID: PMC11555548 - DOI: 10.1001/jamanetworkopen.2024.43416
Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings.
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells.
Cell Stem Cell. 2024;32(2):191-208.e11 - PMID: 39672163 - PMCID: PMC11805672 - DOI: 10.1016/j.stem.2024.11.001
ERBB2/HOXB13 co-amplification with interstitial loss of BRCA1 defines a unique subset of breast cancers.
Breast Cancer Res. 2024;26(1):185 - PMID: 39695741 - PMCID: PMC11657829 - DOI: 10.1186/s13058-024-01943-1
Deaminase-mediated chromatin accessibility profiling with single-allele resolution.
Immunocompetent murine glioblastoma stem-like cell models exhibiting distinct phenotypes.
Neurooncol Adv. 2024;7(1):vdae215 - PMID: 39896074 - PMCID: PMC11783566 - DOI: 10.1093/noajnl/vdae215
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine response in adults with predominantly antibody deficiency.
J Allergy Clin Immunol Glob. 2024;3(2):100234 - PMID: 38544577 - PMCID: PMC10965812 - DOI: 10.1016/j.jacig.2024.100234
Researching COVID to enhance recovery (RECOVER) tissue pathology study protocol: Rationale, objectives, and design.
PLoS One. 2024;19(1):e0285645 - PMID: 38198481 - PMCID: PMC10781091 - DOI: 10.1371/journal.pone.0285645
Microbial transmission in the social microbiome and host health and disease.
The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma.
Gut complement induced by the microbiota combats pathogens and spares commensals.
Cell. 2024;187(4):897-913.e18 - PMID: 38280374 - PMCID: PMC10922926 - DOI: 10.1016/j.cell.2023.12.036
CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas.
Cancers (Basel). 2024;16(2):ePub - PMID: 38275898 - PMCID: PMC10814785 - DOI: 10.3390/cancers16020457
Sudden unexpected death in a middle-aged woman.
J Clin Pathol. 2024;77(5):297-300 - PMID: 38316542 - DOI: 10.1136/jcp-2022-208691
Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations.
Antisynthetase Syndrome Causing Necrotizing Myositis Involving Extraocular Muscles.
Ophthalmic Plast Reconstr Surg. 2024;40(4):e111-e114 - PMID: 38346432 - DOI: 10.1097/IOP.0000000000002628
DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements.
The Minimal Criteria for Active Arteritis in a Temporal Artery Biopsy.
Cardiovasc Pathol. 2024;70:107622 - PMID: 38365063 - DOI: 10.1016/j.carpath.2024.107622
The FLRT3-UNC5B checkpoint pathway inhibits T cell-based cancer immunotherapies.
Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart.
Circulation. 2024;150(1):49-61 - PMID: 38506045 - PMCID: PMC11216864 - DOI: 10.1161/CIRCULATIONAHA.123.066433
A Comparison of Clear Cell Sarcoma to Jaw and Salivary Tumors Bearing EWS Fusions.
Head Neck Pathol. 2024;18(1):25 - PMID: 38526767 - PMCID: PMC10963349 - DOI: 10.1007/s12105-024-01625-6
Exposure to low-intensity blast increases clearance of brain Aβ.
J Neurotrauma. 2024;41(5-6):685-704 - PMID: 38183627 - DOI: 10.1089/neu.2023.0284
Large vessel giant cell arteritis.
Lancet Rheumatol. 2024;6(6):e397-e408 - PMID: 38574745 - DOI: 10.1016/S2665-9913(23)00300-4
Wild-type Transthyretin Amyloid Deposition in an Ascending Aortic Aneurysm.
JACC Case Rep. 2024;29(9):102311 - PMID: 38576771 - PMCID: PMC10990737 - DOI: 10.1016/j.jaccas.2024.102311
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.
ANTsX neuroimaging-derived structural phenotypes of UK Biobank.
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma.
Defining and benchmarking open problems in single-cell analysis.
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Cell. 2024;187(10):2536-2556.e30 - PMID: 38653237 - PMCID: PMC11143475 - DOI: 10.1016/j.cell.2024.03.027
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.
Nat Genet. 2024;56(5):925-937 - PMID: 38658794 - PMCID: PMC11669423 - DOI: 10.1038/s41588-024-01726-6
Correction: Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy.
Cancer Res. 2024;84(9):1534 - PMID: 38693893 - DOI: 10.1158/0008-5472.CAN-24-0718
CRISPR PERSIST-On enables heritable and fine-tunable human gene activation.
MOSAIC enables in situ saturation mutagenesis of genes and CRISPR prime editing guide RNA optimization in human cells.
Recombinant ADAMTS13 for Immune Thrombotic Thrombocytopenic Purpura.
N Engl J Med. 2024;390(18):1690-1698 - PMID: 38718359 - PMCID: PMC11128310 - DOI: 10.1056/NEJMoa2402567

