Case 27-2024: A 24-Year-Old Man with Pain and Dyspnea.
N Engl J Med. 2024;391(9):845-852 - PMID: 39231348 - DOI: 10.1056/NEJMcpc2402491
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
Scalable assessment of genome editing off-targets associated with genetic variants.
Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors.
Cancer Cell. 2024;42(9):1497-1506 - PMID: 39214095 - DOI: 10.1016/j.ccell.2024.08.005
Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors.
Adv Sci (Weinh). 2024;11(38):e2309755 - PMID: 39136172 - PMCID: PMC11481286 - DOI: 10.1002/advs.202309755
EPInformer: A Scalable Deep Learning Framework for Gene Expression Prediction by Integrating Promoter-enhancer Sequences with Multimodal Epigenomic Data.
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma.
JCI Insight. 2024;9(14):ePub - PMID: 39133652 - PMCID: PMC11383371 - DOI: 10.1172/jci.insight.169647
Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma.
Single-cell atlas of the human brain vasculature across development, adulthood and disease.
Nature. 2024;632(8025):603-613 - PMID: 38987604 - PMCID: PMC11324530 - DOI: 10.1038/s41586-024-07493-y
Large B-cell lymphoma with mystery rearrangement: Applying Hi-C to the detection of clinically relevant structural abnormalities.
Br J Haematol. 2024;205(3):1225-1229 - PMID: 38924537 - DOI: 10.1111/bjh.19611
T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation.
Cancer Cell. 2024;42(6):1130-1131 - PMID: 38861925 - PMCID: PMC11253892 - DOI: 10.1016/j.ccell.2024.05.019
Erratum: Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2.
Mol Ther Methods Clin Dev. 2024;32(2):101262 - PMID: 38745896 - PMCID: PMC11090857 - DOI: 10.1016/j.omtm.2024.101262
Recombinant ADAMTS13 for Immune Thrombotic Thrombocytopenic Purpura.
N Engl J Med. 2024;390(18):1690-1698 - PMID: 38718359 - PMCID: PMC11128310 - DOI: 10.1056/NEJMoa2402567
MOSAIC enables in situ saturation mutagenesis of genes and CRISPR prime editing guide RNA optimization in human cells.
CRISPR PERSIST-On enables heritable and fine-tunable human gene activation.
Correction: Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy.
Cancer Res. 2024;84(9):1534 - PMID: 38693893 - DOI: 10.1158/0008-5472.CAN-24-0718
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.
Nat Genet. 2024;56(5):925-937 - PMID: 38658794 - PMCID: PMC11669423 - DOI: 10.1038/s41588-024-01726-6
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Cell. 2024;187(10):2536-2556.e30 - PMID: 38653237 - PMCID: PMC11143475 - DOI: 10.1016/j.cell.2024.03.027
Defining and benchmarking open problems in single-cell analysis.
Case 6-2019: A 29-Year-Old Woman with Nausea, Vomiting, and Diarrhea.
N Engl J Med. 2019;380(8):772-779 - PMID: 30786192 - DOI: 10.1056/NEJMcpc1816407
Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.
Cell. 2019;178(5):1115-1131.e15 - PMID: 31442404 - PMCID: PMC6732196 - DOI: 10.1016/j.cell.2019.07.048
Case 1-2020: An 11-Year-Old Boy with Vomiting and Weight Loss.
N Engl J Med. 2020;382(2):180-189 - PMID: 31914246 - PMCID: PMC8176458 - DOI: 10.1056/NEJMcpc1913469
Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids.
Cell Syst. 2020;10(3):223-239.e9 - PMID: 32191873 - PMCID: PMC8143761 - DOI: 10.1016/j.cels.2020.02.008
X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes.
Semin Cell Dev Biol. 2011;22(4):336-42 - PMID: 21376830 - PMCID: PMC3175323 - DOI: 10.1016/j.semcdb.2011.02.025
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
α-Synuclein: membrane interactions and toxicity in Parkinson's disease.
Annu Rev Cell Dev Biol. 2010;26:211-33 - PMID: 20500090 - DOI: 10.1146/annurev.cellbio.042308.113313
Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape.
Cancer Res. 2011;71(1):19-28 - PMID: 21199795 - PMCID: PMC3074948 - DOI: 10.1158/0008-5472.CAN-10-2602
A novel tissue engineering approach using an endothelial progenitor cell-seeded biopolymer to treat intracranial saccular aneurysms.
J Neurosurg. 2012;117(3):546-54 - PMID: 22746379 - DOI: 10.3171/2012.5.JNS091308
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma.
J Immunother Cancer. 2019;7(1):304 - PMID: 31727131 - PMCID: PMC6857271 - DOI: 10.1186/s40425-019-0806-7
Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
Integrated proteomic, transcriptomic, and biological network analysis of breast carcinoma reveals molecular features of tumorigenesis and clinical relapse.
Mol Cell Proteomics. 2012;11(6):M111.014910 - PMID: 22240506 - PMCID: PMC3433899 - DOI: 10.1074/mcp.M111.014910
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Proc Natl Acad Sci U S A. 2012;109(36):14476-81 - PMID: 22908275 - PMCID: PMC3437859 - DOI: 10.1073/pnas.1203201109
Comprehensive genomic characterization of squamous cell lung cancers.
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Signatures of mutational processes in human cancer.
Oncogenic RIT1 mutations in lung adenocarcinoma.
A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events.
Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.
Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage.
Wild-type Transthyretin Amyloid Deposition in an Ascending Aortic Aneurysm.
JACC Case Rep. 2024;29(9):102311 - PMID: 38576771 - PMCID: PMC10990737 - DOI: 10.1016/j.jaccas.2024.102311
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.
Assessment of 5-year overall survival in bladder cancer patients with incidental prostate cancer identified at radical cystoprostatectomy.
Int Urol Nephrol. 2019;51(9):1527-1535 - PMID: 31183659 - DOI: 10.1007/s11255-019-02181-7
Molecular testing of different cytologic preparations in patients with advanced lung adenocarcinoma: which yields the best results?
J Am Soc Cytopathol. 2016;6(1):16-23 - PMID: 31042629 - DOI: 10.1016/j.jasc.2016.06.002
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.
J Biol Chem. 2015;290(23):14381-90 - PMID: 25882849 - PMCID: PMC4505506 - DOI: 10.1074/jbc.M114.631945
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.
Tissue-Specific Oncogenic Activity of KRASA146T.
Cancer Discov. 2019;9(6):738-755 - PMID: 30952657 - PMCID: PMC6548671 - DOI: 10.1158/2159-8290.CD-18-1220
A molecular roadmap of reprogramming somatic cells into iPS cells.
Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases.
Am J Surg Pathol. 2014;38(10):1319-29 - PMID: 25188868 - PMCID: PMC4162848 - DOI: 10.1097/PAS.0000000000000317

