A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration.
Insertions and Deletions Target Lineage-Defining Genes in Human Cancers.
Cell. 2017;168(3):460-472.e14 - PMID: 28089356 - PMCID: PMC5564321 - DOI: 10.1016/j.cell.2016.12.025
High-throughput Phenotyping of Lung Cancer Somatic Mutations.
Cancer Cell. 2016;30(2):214-228 - PMID: 27478040 - PMCID: PMC5003022 - DOI: 10.1016/j.ccell.2016.06.022
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.
Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.
Genetic modifiers of EGFR dependence in non-small cell lung cancer.
Proc Natl Acad Sci U S A. 2014;111(52):18661-6 - PMID: 25512530 - PMCID: PMC4284598 - DOI: 10.1073/pnas.1412228112
Comprehensive molecular profiling of lung adenocarcinoma.
Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.
A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events.
Oncogenic RIT1 mutations in lung adenocarcinoma.
Signatures of mutational processes in human cancer.
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Comprehensive genomic characterization of squamous cell lung cancers.
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Proc Natl Acad Sci U S A. 2012;109(36):14476-81 - PMID: 22908275 - PMCID: PMC3437859 - DOI: 10.1073/pnas.1203201109
Integrated proteomic, transcriptomic, and biological network analysis of breast carcinoma reveals molecular features of tumorigenesis and clinical relapse.
Mol Cell Proteomics. 2012;11(6):M111.014910 - PMID: 22240506 - PMCID: PMC3433899 - DOI: 10.1074/mcp.M111.014910
Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma.
J Immunother Cancer. 2019;7(1):304 - PMID: 31727131 - PMCID: PMC6857271 - DOI: 10.1186/s40425-019-0806-7
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
A novel tissue engineering approach using an endothelial progenitor cell-seeded biopolymer to treat intracranial saccular aneurysms.
J Neurosurg. 2012;117(3):546-54 - PMID: 22746379 - DOI: 10.3171/2012.5.JNS091308
Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape.
Cancer Res. 2011;71(1):19-28 - PMID: 21199795 - PMCID: PMC3074948 - DOI: 10.1158/0008-5472.CAN-10-2602
α-Synuclein: membrane interactions and toxicity in Parkinson's disease.
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Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes.
Semin Cell Dev Biol. 2011;22(4):336-42 - PMID: 21376830 - PMCID: PMC3175323 - DOI: 10.1016/j.semcdb.2011.02.025
Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids.
Cell Syst. 2020;10(3):223-239.e9 - PMID: 32191873 - PMCID: PMC8143761 - DOI: 10.1016/j.cels.2020.02.008
Case 1-2020: An 11-Year-Old Boy with Vomiting and Weight Loss.
N Engl J Med. 2020;382(2):180-189 - PMID: 31914246 - PMCID: PMC8176458 - DOI: 10.1056/NEJMcpc1913469
Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.
Cell. 2019;178(5):1115-1131.e15 - PMID: 31442404 - PMCID: PMC6732196 - DOI: 10.1016/j.cell.2019.07.048
Case 6-2019: A 29-Year-Old Woman with Nausea, Vomiting, and Diarrhea.
N Engl J Med. 2019;380(8):772-779 - PMID: 30786192 - DOI: 10.1056/NEJMcpc1816407
Defining and benchmarking open problems in single-cell analysis.
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Cell. 2024;187(10):2536-2556.e30 - PMID: 38653237 - PMCID: PMC11143475 - DOI: 10.1016/j.cell.2024.03.027
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.
Nat Genet. 2024;56(5):925-937 - PMID: 38658794 - PMCID: PMC11669423 - DOI: 10.1038/s41588-024-01726-6
Correction: Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy.
Cancer Res. 2024;84(9):1534 - PMID: 38693893 - DOI: 10.1158/0008-5472.CAN-24-0718
CRISPR PERSIST-On enables heritable and fine-tunable human gene activation.
MOSAIC enables in situ saturation mutagenesis of genes and CRISPR prime editing guide RNA optimization in human cells.
Recombinant ADAMTS13 for Immune Thrombotic Thrombocytopenic Purpura.
N Engl J Med. 2024;390(18):1690-1698 - PMID: 38718359 - PMCID: PMC11128310 - DOI: 10.1056/NEJMoa2402567
Erratum: Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2.
Mol Ther Methods Clin Dev. 2024;32(2):101262 - PMID: 38745896 - PMCID: PMC11090857 - DOI: 10.1016/j.omtm.2024.101262
T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation.
Cancer Cell. 2024;42(6):1130-1131 - PMID: 38861925 - PMCID: PMC11253892 - DOI: 10.1016/j.ccell.2024.05.019
Large B-cell lymphoma with mystery rearrangement: Applying Hi-C to the detection of clinically relevant structural abnormalities.
Br J Haematol. 2024;205(3):1225-1229 - PMID: 38924537 - DOI: 10.1111/bjh.19611
Single-cell atlas of the human brain vasculature across development, adulthood and disease.
Nature. 2024;632(8025):603-613 - PMID: 38987604 - PMCID: PMC11324530 - DOI: 10.1038/s41586-024-07493-y
Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma.
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma.
JCI Insight. 2024;9(14):ePub - PMID: 39133652 - PMCID: PMC11383371 - DOI: 10.1172/jci.insight.169647
EPInformer: A Scalable Deep Learning Framework for Gene Expression Prediction by Integrating Promoter-enhancer Sequences with Multimodal Epigenomic Data.
Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors.
Adv Sci (Weinh). 2024;11(38):e2309755 - PMID: 39136172 - PMCID: PMC11481286 - DOI: 10.1002/advs.202309755
Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors.
Cancer Cell. 2024;42(9):1497-1506 - PMID: 39214095 - DOI: 10.1016/j.ccell.2024.08.005
Scalable assessment of genome editing off-targets associated with genetic variants.
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
Case 27-2024: A 24-Year-Old Man with Pain and Dyspnea.
N Engl J Med. 2024;391(9):845-852 - PMID: 39231348 - DOI: 10.1056/NEJMcpc2402491
Normative Neuroimaging Library: Designing a Comprehensive and Demographically Diverse Dataset of Healthy Controls to Support Traumatic Brain Injury Diagnostic and Therapeutic Development.
J Neurotrauma. 2024;41(23-24):2497-2512 - PMID: 39235436 - DOI: 10.1089/neu.2024.0128
Selective Enhancer Gain of Function Deregulates MYC Expression in Multiple Myeloma.
Cancer Res. 2024;84(24):4173-4183 - PMID: 39312195 - PMCID: PMC11649448 - DOI: 10.1158/0008-5472.CAN-24-1440
CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing.
Glioblastoma-cortical organoids recapitulate cell state heterogeneity and intercellular transfer.
Cancer Discov. 2024;15(2):299-315 - PMID: 39373549 - PMCID: PMC11803396 - DOI: 10.1158/2159-8290.CD-23-1336

